| Pos | Name | Team | Pa | Ru | Rc | TD | 2Pt | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Jonathan Taylor | BB | 0 | 1356 | 304 | 18 | 1 | 0 | 0 | 162 |
| 2. | RB | Jahmyr Gibbs | AO | 0 | 1062 | 474 | 16 | 0 | 0 | 0 | 144 |
| 3. | RB | Christian McCaffrey | MB | 0 | 849 | 806 | 13 | 0 | 0 | 0 | 130 |
| 4. | RB | De'Von Achane | CR | 0 | 1126 | 383 | 11 | 0 | 0 | 0 | 114 |
| 5. | RB | James Cook | WG | 0 | 1308 | 267 | 9 | 0 | 0 | 0 | 104 |
| RB | Josh Jacobs | UH | 0 | 817 | 251 | 12 | 0 | 0 | 0 | 104 | |
| 7. | RB | Javonte Williams | MB | 0 | 1022 | 128 | 11 | 0 | 0 | 0 | 98 |
| 8. | RB | Derrick Henry | BuB | 0 | 1025 | 150 | 10 | 0 | 0 | 0 | 96 |
| RB | Kyren Williams | LMM | 0 | 952 | 197 | 11 | 0 | 0 | 0 | 96 | |
| 10. | RB | Bijan Robinson | LMM | 0 | 1081 | 602 | 7 | 1 | 0 | 0 | 94 |
| 11. | RB | Travis Etienne Jr. | BuB | 0 | 917 | 181 | 9 | 0 | 0 | 0 | 88 |
| 12. | RB | Saquon Barkley | LFT | 0 | 818 | 261 | 7 | 0 | 0 | 0 | 74 |
| 13. | RB | Ashton Jeanty | UH | 0 | 674 | 259 | 8 | 0 | 0 | 0 | 72 |
| 14. | RB | RJ Harvey | WG | 0 | 354 | 247 | 9 | 0 | 0 | 0 | 70 |
| 15. | RB | David Montgomery | FM | 3 | 603 | 164 | 8 | 1 | 0 | 0 | 68 |
| 16. | RB | Breece Hall | MT | 4 | 877 | 309 | 5 | 0 | 0 | 0 | 66 |
| RB | D'Andre Swift | SD | 0 | 837 | 256 | 6 | 0 | 0 | 0 | 66 | |
| 18. | RB | Rico Dowdle | UH | 0 | 846 | 234 | 5 | 0 | 0 | 0 | 64 |
| 19. | RB | Quinshon Judkins | BuB | 0 | 629 | 135 | 6 | 1 | 0 | 0 | 58 |
| RB | Chase Brown | LFT | 0 | 618 | 240 | 5 | 0 | 0 | 0 | 58 | |
| 21. | RB | TreVeyon Henderson | BP | 0 | 625 | 199 | 6 | 0 | 0 | 0 | 54 |
| 22. | RB | Kenneth Walker III | SD | 0 | 762 | 174 | 4 | 0 | 0 | 0 | 52 |
| 23. | RB | Jaylen Warren | MT | 0 | 567 | 169 | 5 | 0 | 0 | 0 | 50 |
| 24. | RB | Kareem Hunt | MHB | 0 | 424 | 89 | 6 | 0 | 0 | 0 | 48 |
| 25. | RB | Kimani Vidal | BB | 0 | 569 | 122 | 4 | 0 | 0 | 0 | 44 |