| Pos | Name | Team | Week | Pass | Rush | Rec | TD | Conv | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Jonathan Taylor | BB | 10/2025 | 0 | 244 | 42 | 3 | 0 | 0 | 0 | 28 |
| RB | Jahmyr Gibbs | AO | 12/2025 | 0 | 219 | 45 | 3 | 0 | 0 | 0 | 28 | |
| 3. | RB | Jonathan Taylor | BB | 8/2025 | 0 | 153 | 21 | 3 | 0 | 0 | 0 | 24 |
| RB | Jahmyr Gibbs | AO | 10/2025 | 0 | 142 | 30 | 3 | 0 | 0 | 0 | 24 | |
| RB | Ashton Jeanty | UH | 4/2025 | 0 | 138 | 17 | 3 | 0 | 0 | 0 | 24 | |
| 6. | RB | Breece Hall | MT | 8/2025 | 4 | 133 | 14 | 3 | 0 | 0 | 0 | 22 |
| RB | Sean Tucker | AE | 11/2025 | 0 | 106 | 34 | 3 | 0 | 0 | 0 | 22 | |
| RB | Jonathan Taylor | BB | 3/2025 | 0 | 102 | 16 | 3 | 0 | 0 | 0 | 22 | |
| RB | Cam Skattebo | MT | 6/2025 | 0 | 98 | 12 | 3 | 0 | 0 | 0 | 22 | |
| RB | Jonathan Taylor | BB | 7/2025 | 0 | 94 | 38 | 3 | 0 | 0 | 0 | 22 | |
| RB | Christian McCaffrey | MB | 11/2025 | 0 | 81 | 40 | 3 | 0 | 0 | 0 | 22 | |
| RB | Jonathan Taylor | BB | 5/2025 | 0 | 66 | 20 | 3 | 1 | 0 | 0 | 22 | |
| RB | Jahmyr Gibbs | AO | 14/2025 | 0 | 43 | 77 | 3 | 0 | 0 | 0 | 22 | |
| 14. | RB | James Cook | WG | 8/2025 | 0 | 216 | 0 | 2 | 0 | 0 | 0 | 20 |
| RB | De'Von Achane | CR | 10/2025 | 0 | 174 | 51 | 2 | 0 | 0 | 0 | 20 | |
| RB | Jahmyr Gibbs | AO | 7/2025 | 0 | 136 | 82 | 2 | 0 | 0 | 0 | 20 | |
| RB | Christian McCaffrey | MB | 7/2025 | 0 | 129 | 72 | 2 | 0 | 0 | 0 | 20 | |
| RB | Quinshon Judkins | BuB | 7/2025 | 0 | 84 | 0 | 3 | 0 | 0 | 0 | 20 | |
| RB | TreVeyon Henderson | BP | 11/2025 | 0 | 62 | 31 | 3 | 0 | 0 | 0 | 20 | |
| RB | RJ Harvey | WG | 8/2025 | 0 | 46 | 5 | 3 | 0 | 0 | 0 | 20 | |
| 21. | RB | Derrick Henry | BuB | 1/2025 | 0 | 169 | 13 | 2 | 0 | 0 | 0 | 18 |
| RB | David Montgomery | FM | 3/2025 | 0 | 151 | 13 | 2 | 0 | 0 | 0 | 18 | |
| RB | Saquon Barkley | LFT | 8/2025 | 0 | 150 | 24 | 2 | 0 | 0 | 0 | 18 | |
| RB | TreVeyon Henderson | BP | 10/2025 | 0 | 147 | 3 | 2 | 0 | 0 | 0 | 18 | |
| RB | De'Von Achane | CR | 6/2025 | 0 | 128 | 22 | 2 | 0 | 0 | 0 | 18 |