| Pos | Name | Team | Pass | Rush | Rec | TD | Conv | FG | XP | Total | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | QB | Donovan McNabb | CR | 903 | 39 | 0 | 7 | 1 | 0 | 0 | 52 |
| 2. | RB | Chris Johnson | CR | 0 | 363 | 161 | 4 | 0 | 0 | 0 | 40 |
| 3. | QB | Aaron Rodgers | SD | 800 | 25 | 0 | 5 | 2 | 0 | 0 | 38 |
| 4. | RB | Frank Gore | SD | 0 | 345 | 110 | 2 | 0 | 0 | 0 | 26 |
| TE | Todd Heap | CR | 0 | 0 | 131 | 4 | 0 | 0 | 0 | 26 | |
| 6. | QB | Ben Roethlisberger | FM | 503 | 7 | 0 | 3 | 0 | 0 | 0 | 24 |
| K | Sebastian Janikowski | CR | 0 | 0 | 0 | 0 | 0 | 7 | 3 | 24 | |
| 8. | QB | Drew Brees | LFT | 296 | -2 | 0 | 3 | 0 | 0 | 0 | 18 |
| WR | Andre Johnson | LFT | 0 | 3 | 193 | 2 | 0 | 0 | 0 | 18 | |
| 10. | K | Shayne Graham | SD | 0 | 0 | 0 | 0 | 0 | 4 | 3 | 15 |
| 11. | TE | Vernon Davis | SD | 0 | 0 | 95 | 2 | 0 | 0 | 0 | 12 |
| WR | Hakeem Nicks | CR | 0 | -1 | 220 | 1 | 0 | 0 | 0 | 12 | |
| 13. | QB | Matt Schaub | MT | 367 | -3 | 0 | 1 | 0 | 0 | 0 | 10 |
| RB | Laurence Maroney | CR | 0 | 197 | 17 | 1 | 0 | 0 | 0 | 10 | |
| RB | Jerome Harrison | SD | 0 | 157 | 10 | 1 | 0 | 0 | 0 | 10 | |
| RB | Maurice Jones-Drew | CR | 0 | 122 | 59 | 1 | 0 | 0 | 0 | 10 | |
| WR | Miles Austin | FM | 0 | 0 | 139 | 1 | 0 | 0 | 0 | 10 | |
| K | Rian Lindell | SD | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 10 | |
| 19. | RB | LaDainian Tomlinson | CC | 0 | 50 | 9 | 1 | 0 | 0 | 0 | 8 |
| WR | Wes Welker | SD | 0 | 5 | 283 | 0 | 0 | 0 | 0 | 8 | |
| WR | Johnny Knox | CR | 0 | 0 | 112 | 1 | 0 | 0 | 0 | 8 | |
| TE | Fred Davis | 0 | 0 | 65 | 1 | 0 | 0 | 0 | 8 | ||
| K | Nate Kaeding | LFT | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 8 | |
| 24. | K | David Akers | CC | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 7 |
| 25. | QB | Philip Rivers | CC | 272 | 1 | 0 | 1 | 0 | 0 | 0 | 6 |