| Pos | Name | Team | Week | Pass | Rush | Rec | TD | Conv | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Arian Foster | UH | 1/2010 | 0 | 231 | 7 | 3 | 0 | 0 | 0 | 26 |
| RB | Jahvid Best | UH | 2/2010 | 0 | 78 | 154 | 3 | 0 | 0 | 0 | 26 | |
| 3. | RB | Peyton Hillis | MT | 12/2010 | 0 | 131 | 63 | 3 | 0 | 0 | 0 | 24 |
| 4. | RB | LeSean McCoy | CC | 2/2010 | 0 | 120 | 8 | 3 | 0 | 0 | 0 | 22 |
| RB | Adrian Peterson | WG | 13/2010 | 0 | 107 | 1 | 3 | 0 | 0 | 0 | 22 | |
| 6. | RB | Peyton Hillis | MT | 9/2010 | 0 | 184 | 36 | 2 | 0 | 0 | 0 | 20 |
| RB | Matt Forte | SD | 1/2010 | 0 | 50 | 151 | 2 | 0 | 0 | 0 | 20 | |
| 8. | RB | Matt Forte | SD | 5/2010 | 0 | 166 | 22 | 2 | 0 | 0 | 0 | 18 |
| RB | Adrian Peterson | WG | 3/2010 | 0 | 160 | 30 | 2 | 0 | 0 | 0 | 18 | |
| RB | Chris Johnson | CR | 1/2010 | 0 | 142 | 8 | 2 | 0 | 0 | 0 | 18 | |
| RB | Fred Jackson | MB | 10/2010 | 0 | 133 | 37 | 2 | 0 | 0 | 0 | 18 | |
| RB | Ray Rice | LMM | 5/2010 | 0 | 133 | 26 | 2 | 0 | 0 | 0 | 18 | |
| RB | LaDainian Tomlinson | CC | 4/2010 | 0 | 133 | 22 | 2 | 0 | 0 | 0 | 18 | |
| RB | Arian Foster | UH | 4/2010 | 0 | 131 | 56 | 2 | 0 | 0 | 0 | 18 | |
| RB | Arian Foster | UH | 9/2010 | 0 | 127 | 70 | 2 | 0 | 0 | 0 | 18 | |
| RB | Frank Gore | SD | 2/2010 | 0 | 112 | 56 | 2 | 0 | 0 | 0 | 18 | |
| 17. | RB | Chris Johnson | CR | 5/2010 | 0 | 131 | 1 | 2 | 0 | 0 | 0 | 16 |
| RB | Chris Johnson | CR | 3/2010 | 0 | 125 | 0 | 2 | 0 | 0 | 0 | 16 | |
| RB | Michael Turner | FM | 7/2010 | 0 | 121 | 23 | 2 | 0 | 0 | 0 | 16 | |
| RB | LeGarrette Blount | MT | 8/2010 | 0 | 120 | 9 | 2 | 0 | 0 | 0 | 16 | |
| RB | BenJarvus Green-Ellis | MHB | 8/2010 | 0 | 112 | 11 | 2 | 0 | 0 | 0 | 16 | |
| RB | Michael Turner | FM | 9/2010 | 0 | 107 | 0 | 2 | 0 | 0 | 0 | 16 | |
| RB | Maurice Jones-Drew | CR | 4/2010 | 0 | 105 | 16 | 2 | 0 | 0 | 0 | 16 | |
| RB | Brandon Jacobs | UH | 13/2010 | 0 | 103 | 0 | 2 | 0 | 0 | 0 | 16 | |
| RB | Maurice Jones-Drew | CR | 10/2010 | 0 | 100 | 23 | 2 | 0 | 0 | 0 | 16 |