| Pos | Name | Team | Pa | Ru | Rc | TD | 2Pt | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Christian McCaffrey | MB | 0 | 1177 | 437 | 17 | 0 | 0 | 0 | 154 |
| 2. | RB | Raheem Mostert | MB | 0 | 924 | 170 | 18 | 0 | 0 | 0 | 138 |
| 3. | RB | Derrick Henry | BuB | 2 | 874 | 202 | 11 | 0 | 0 | 0 | 98 |
| 4. | RB | Travis Etienne Jr. | BuB | 0 | 806 | 383 | 10 | 2 | 0 | 0 | 96 |
| 5. | RB | David Montgomery | FM | 0 | 770 | 106 | 10 | 1 | 0 | 0 | 86 |
| 6. | RB | Kyren Williams | LMM | 0 | 749 | 187 | 8 | 0 | 0 | 0 | 82 |
| 7. | RB | Joe Mixon | BuB | 0 | 768 | 327 | 8 | 0 | 0 | 0 | 80 |
| RB | Brian Robinson Jr. | CR | 0 | 664 | 325 | 8 | 1 | 0 | 0 | 80 | |
| 9. | RB | Bijan Robinson | LMM | 0 | 790 | 320 | 7 | 0 | 0 | 0 | 76 |
| RB | Rachaad White | MB | 0 | 745 | 419 | 7 | 0 | 0 | 0 | 76 | |
| 11. | RB | Saquon Barkley | LFT | 0 | 783 | 183 | 7 | 0 | 0 | 0 | 72 |
| RB | Alvin Kamara | CC | 0 | 564 | 402 | 6 | 3 | 0 | 0 | 72 | |
| 13. | RB | Isiah Pacheco | MHB | 0 | 780 | 209 | 7 | 0 | 0 | 0 | 70 |
| 14. | RB | Kenneth Walker III | SD | 0 | 634 | 206 | 7 | 0 | 0 | 0 | 68 |
| RB | Gus Edwards | MT | 0 | 511 | 130 | 9 | 0 | 0 | 0 | 68 | |
| 16. | RB | Tony Pollard | BP | 0 | 796 | 285 | 5 | 1 | 0 | 0 | 66 |
| RB | Jahmyr Gibbs | AO | 0 | 692 | 288 | 6 | 0 | 0 | 0 | 66 | |
| 18. | RB | Josh Jacobs | UH | 0 | 805 | 296 | 6 | 0 | 0 | 0 | 64 |
| 19. | RB | James Cook | WG | 0 | 789 | 391 | 4 | 0 | 0 | 0 | 62 |
| RB | Austin Ekeler | CC | 0 | 497 | 344 | 6 | 0 | 0 | 0 | 62 | |
| 21. | RB | D'Andre Swift | SD | 0 | 818 | 209 | 5 | 0 | 0 | 0 | 60 |
| 22. | RB | Breece Hall | MT | 0 | 625 | 435 | 5 | 0 | 0 | 0 | 56 |
| 23. | RB | Rhamondre Stevenson | WG | 0 | 619 | 238 | 4 | 0 | 0 | 0 | 48 |
| 24. | RB | De'Von Achane | CR | 0 | 373 | 91 | 5 | 0 | 0 | 0 | 46 |
| 25. | RB | Javonte Williams | LMM | 0 | 650 | 180 | 3 | 1 | 0 | 0 | 44 |