| Pos | Name | Team | Pa | Ru | Rc | TD | 2Pt | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | RB | Saquon Barkley | LFT | 0 | 1623 | 267 | 13 | 3 | 0 | 0 | 148 |
| 2. | RB | Derrick Henry | BuB | 0 | 1408 | 125 | 15 | 0 | 0 | 0 | 136 |
| 3. | RB | Kyren Williams | LMM | 0 | 1013 | 155 | 14 | 0 | 0 | 0 | 120 |
| 4. | RB | Jahmyr Gibbs | AO | 0 | 1016 | 312 | 12 | 0 | 0 | 0 | 114 |
| 5. | RB | Josh Jacobs | UH | 0 | 1053 | 260 | 12 | 0 | 0 | 0 | 112 |
| 6. | RB | Joe Mixon | BuB | 0 | 887 | 244 | 12 | 0 | 0 | 0 | 108 |
| 7. | RB | David Montgomery | FM | 3 | 772 | 310 | 13 | 0 | 0 | 0 | 106 |
| 8. | RB | Bijan Robinson | LMM | 0 | 977 | 395 | 9 | 1 | 0 | 0 | 100 |
| 9. | RB | James Cook | WG | 0 | 723 | 204 | 12 | 0 | 0 | 0 | 94 |
| 10. | RB | De'Von Achane | CR | 0 | 524 | 465 | 10 | 0 | 0 | 0 | 92 |
| 11. | RB | Alvin Kamara | CC | 0 | 938 | 485 | 7 | 0 | 0 | 0 | 88 |
| 12. | RB | James Conner | CC | 0 | 863 | 333 | 6 | 3 | 0 | 0 | 78 |
| 13. | RB | Chase Brown | BuB | 0 | 551 | 271 | 7 | 1 | 0 | 0 | 70 |
| RB | Kenneth Walker III | SD | 0 | 542 | 271 | 8 | 0 | 0 | 0 | 70 | |
| 15. | RB | Rhamondre Stevenson | WG | 0 | 671 | 139 | 7 | 2 | 0 | 0 | 66 |
| 16. | RB | Najee Harris | BP | 0 | 877 | 249 | 5 | 0 | 0 | 0 | 64 |
| RB | Jonathan Taylor | BB | 0 | 804 | 118 | 6 | 0 | 0 | 0 | 64 | |
| 18. | RB | Breece Hall | MT | 0 | 692 | 401 | 5 | 1 | 0 | 0 | 62 |
| RB | Bucky Irving | AE | 0 | 580 | 272 | 6 | 0 | 0 | 0 | 62 | |
| 20. | RB | Tony Pollard | BP | 0 | 937 | 232 | 4 | 0 | 0 | 0 | 60 |
| RB | Aaron Jones Sr. | FM | 0 | 800 | 279 | 5 | 0 | 0 | 0 | 60 | |
| RB | D'Andre Swift | SD | 0 | 742 | 315 | 5 | 1 | 0 | 0 | 60 | |
| RB | Brian Robinson Jr. | CR | 0 | 569 | 105 | 7 | 0 | 0 | 0 | 60 | |
| 24. | RB | Chuba Hubbard | CR | 0 | 563 | 44 | 6 | 1 | 0 | 0 | 58 |
| 25. | RB | Tyrone Tracy Jr. | LFT | 0 | 635 | 175 | 5 | 0 | 0 | 0 | 56 |