| Pos | Name | Team | Week | Pass | Rush | Rec | TD | Conv | FG | XP | Pts | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. | QB | Mitch Trubisky | CR | 4/2018 | 354 | 53 | 0 | 6 | 0 | 0 | 0 | 42 |
| 2. | QB | Patrick Mahomes | BuB | 11/2018 | 478 | 28 | 0 | 6 | 0 | 0 | 0 | 41 |
| 3. | QB | Patrick Mahomes | BuB | 2/2018 | 326 | 18 | 0 | 6 | 0 | 0 | 0 | 40 |
| 4. | QB | Jared Goff | MB | 4/2018 | 465 | 7 | 0 | 5 | 0 | 0 | 0 | 35 |
| QB | Jared Goff | MB | 11/2018 | 413 | 6 | 0 | 5 | 0 | 0 | 0 | 35 | |
| 6. | QB | Drew Brees | CC | 3/2018 | 396 | 7 | 0 | 5 | 0 | 0 | 0 | 34 |
| QB | Ben Roethlisberger | LMM | 10/2018 | 328 | 27 | 0 | 5 | 0 | 0 | 0 | 34 | |
| 8. | QB | Andrew Luck | MT | 4/2018 | 464 | 11 | 0 | 4 | 1 | 0 | 0 | 31 |
| QB | Ben Roethlisberger | LMM | 2/2018 | 452 | 9 | 0 | 4 | 1 | 0 | 0 | 31 | |
| QB | Kirk Cousins | MHB | 2/2018 | 425 | 5 | 0 | 4 | 1 | 0 | 0 | 31 | |
| 11. | QB | Deshaun Watson | LFT | 8/2018 | 239 | 14 | 0 | 5 | 0 | 0 | 0 | 30 |
| 12. | QB | Jameis Winston | FM | 6/2018 | 395 | 31 | 0 | 4 | 0 | 0 | 0 | 28 |
| QB | Drew Brees | CC | 11/2018 | 363 | 0 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Patrick Mahomes | BuB | 7/2018 | 358 | 45 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Mitch Trubisky | CR | 10/2018 | 355 | 18 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Patrick Mahomes | BuB | 6/2018 | 352 | 9 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Drew Brees | CC | 9/2018 | 346 | 16 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Tom Brady | BP | 5/2018 | 341 | -1 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Patrick Mahomes | BuB | 8/2018 | 303 | -1 | 0 | 4 | 0 | 0 | 0 | 28 | |
| QB | Andrew Luck | MT | 6/2018 | 301 | 7 | 0 | 4 | 0 | 0 | 0 | 28 | |
| 21. | QB | Patrick Mahomes | BuB | 13/2018 | 295 | 52 | 0 | 4 | 0 | 0 | 0 | 26 |
| 22. | QB | Aaron Rodgers | SD | 5/2018 | 442 | 10 | 0 | 3 | 1 | 0 | 0 | 25 |
| QB | Drew Brees | CC | 1/2018 | 439 | 0 | 0 | 3 | 1 | 0 | 0 | 25 | |
| QB | Philip Rivers | AE | 1/2018 | 424 | 0 | 0 | 3 | 1 | 0 | 0 | 25 | |
| QB | Kirk Cousins | MHB | 4/2018 | 422 | 28 | 0 | 3 | 1 | 0 | 0 | 25 |